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	<title>Comments on: What&#8217;s Happening with Research and Development?</title>
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	<description>Value Investing Blog</description>
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		<title>By: Joseph</title>
		<link>http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development/#comment-1880</link>
		<dc:creator>Joseph</dc:creator>
		<pubDate>Wed, 25 Jun 2008 04:23:03 +0000</pubDate>
		<guid isPermaLink="false">http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development#comment-1880</guid>
		<description>Joe:

One point on TEVA.  You WERE SPOT ON in terms on them slapping a label on a bottle and sending to you nearest Walgreens! What is even better for a company like TEVA is that the sales force is virtually 0 compared to Lilly, GSK, and Pfizer and the marketing is the same as once a product goes generic- the presence and marketing go generic as well.  This was a great catch on your part as usual!

And by the way- I&#039;d like to comment on Rene and her thoughts on Pfizer.  Every company has had blockbusters (Lipitor and Viagra are great and you missed Zoloft).  But look at the future pipeline for Pfizer- not just the $$$ being placed in to see what their future looks like- their is a reason they have had some serious layoffs--- the future may not be as bright as the past</description>
		<content:encoded><![CDATA[<p>Joe:</p>
<p>One point on TEVA.  You WERE SPOT ON in terms on them slapping a label on a bottle and sending to you nearest Walgreens! What is even better for a company like TEVA is that the sales force is virtually 0 compared to Lilly, GSK, and Pfizer and the marketing is the same as once a product goes generic- the presence and marketing go generic as well.  This was a great catch on your part as usual!</p>
<p>And by the way- I&#8217;d like to comment on Rene and her thoughts on Pfizer.  Every company has had blockbusters (Lipitor and Viagra are great and you missed Zoloft).  But look at the future pipeline for Pfizer- not just the $$$ being placed in to see what their future looks like- their is a reason they have had some serious layoffs&#8212; the future may not be as bright as the past</p>
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		<title>By: Rene</title>
		<link>http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development/#comment-1872</link>
		<dc:creator>Rene</dc:creator>
		<pubDate>Tue, 24 Jun 2008 03:57:42 +0000</pubDate>
		<guid isPermaLink="false">http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development#comment-1872</guid>
		<description>Robert, I don&#039;t disagree with your overall analysis.  I guess my badly expressed point is that pharma has some exciting companies which should do very, very well and some real clunkers which may profit from snake oil for a while, but will lose out in the long run.  I was trying to make the case for Pfizer being one of the former.</description>
		<content:encoded><![CDATA[<p>Robert, I don&#8217;t disagree with your overall analysis.  I guess my badly expressed point is that pharma has some exciting companies which should do very, very well and some real clunkers which may profit from snake oil for a while, but will lose out in the long run.  I was trying to make the case for Pfizer being one of the former.</p>
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		<title>By: OpenMinded</title>
		<link>http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development/#comment-1870</link>
		<dc:creator>OpenMinded</dc:creator>
		<pubDate>Tue, 24 Jun 2008 02:03:14 +0000</pubDate>
		<guid isPermaLink="false">http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development#comment-1870</guid>
		<description>Hello, 

Joe: I completely understand. Reading Fisher as a supplement could be the reason Buffet says he is 85% Graham and 15% fisher. 

Great site, by the way.</description>
		<content:encoded><![CDATA[<p>Hello, </p>
<p>Joe: I completely understand. Reading Fisher as a supplement could be the reason Buffet says he is 85% Graham and 15% fisher. </p>
<p>Great site, by the way.</p>
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		<title>By: Robert Crawford</title>
		<link>http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development/#comment-1869</link>
		<dc:creator>Robert Crawford</dc:creator>
		<pubDate>Mon, 23 Jun 2008 20:00:29 +0000</pubDate>
		<guid isPermaLink="false">http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development#comment-1869</guid>
		<description>Rene, the boomer generation in retirement will nearly double today&#039;s senior population from around 45 million to over 80 million by 2030.  If we take to heart the declaration by Mark Twain that only death and taxes are a certainty, we can rest comfortably in the knowledge that my generation will eventually kick the bucket -- hopefully, after paying taxes.  This whole death thing is a positive for Pharma (big and small) because over 70 percent of average healthcare costs are generated in the last five years of life.  In other words, elder care is about more than Viagra and tummy tucks.  

Indeed, things are improving for the medical industrial complex, due to increasing life expectancy and the conversion of an increasing number of diagnoses from mortal conditions to chronic %u2013 %u201Ccan&#039;t cure it but it won&#039;t kill you%u201D maladies.  We have already seen this with the number one killer of American&#039;s, cardiac conditions of every variety and stripe, and an increasing number of the second most prominent cause of death, cancer.  In fact, it wasn&#039;t long ago that John McCain&#039;s melanoma would have ended his presidential prospects via the mortician&#039;s primary ... a la Paul Tsongas.  

Add this to life expectancies that have grown from 47 years to 79 years since 1900 ( projected to approach to nearly 100 during the current lifetimes for boomers) and you have two realizations.  First, the government will have no choice but to fund treatment (can&#039;t convert healthcare into a means lottery, where the wealthy live 30-to-40 years more than the poor), and, second, government will have no choice but to insure that medical science remains sufficiently profitable to provide a respectable and R&amp;D-risk-adjusted return on the investor&#039;s capital -- even if the retirement age is extended to accomplish this.  

I believe, as well, that government will have no choice but to extend the period of patent exclusivity for novel (new) therapeutics, rather than reducing it, as was done during the first term of this President Bush.  The effect of reducing the marketable life of developed products shortens the time during which new medications earn a return on investment, making each new product more expensive before it graduates to generic status.  This shorter product life also urges quicker churning of new, patent-protected products in to the market, which similarly increases costs to the consumer and, more importantly, the institutional payer (i.e., insurance, the most prominent of which is Medicare).

Thanks,

Robert

PS.  Joe, hope all is well with you, your bride, and the kids.  

</description>
		<content:encoded><![CDATA[<p>Rene, the boomer generation in retirement will nearly double today&#8217;s senior population from around 45 million to over 80 million by 2030.  If we take to heart the declaration by Mark Twain that only death and taxes are a certainty, we can rest comfortably in the knowledge that my generation will eventually kick the bucket &#8212; hopefully, after paying taxes.  This whole death thing is a positive for Pharma (big and small) because over 70 percent of average healthcare costs are generated in the last five years of life.  In other words, elder care is about more than Viagra and tummy tucks.  </p>
<p>Indeed, things are improving for the medical industrial complex, due to increasing life expectancy and the conversion of an increasing number of diagnoses from mortal conditions to chronic %u2013 %u201Ccan&#8217;t cure it but it won&#8217;t kill you%u201D maladies.  We have already seen this with the number one killer of American&#8217;s, cardiac conditions of every variety and stripe, and an increasing number of the second most prominent cause of death, cancer.  In fact, it wasn&#8217;t long ago that John McCain&#8217;s melanoma would have ended his presidential prospects via the mortician&#8217;s primary &#8230; a la Paul Tsongas.  </p>
<p>Add this to life expectancies that have grown from 47 years to 79 years since 1900 ( projected to approach to nearly 100 during the current lifetimes for boomers) and you have two realizations.  First, the government will have no choice but to fund treatment (can&#8217;t convert healthcare into a means lottery, where the wealthy live 30-to-40 years more than the poor), and, second, government will have no choice but to insure that medical science remains sufficiently profitable to provide a respectable and R&#038;D-risk-adjusted return on the investor&#8217;s capital &#8212; even if the retirement age is extended to accomplish this.  </p>
<p>I believe, as well, that government will have no choice but to extend the period of patent exclusivity for novel (new) therapeutics, rather than reducing it, as was done during the first term of this President Bush.  The effect of reducing the marketable life of developed products shortens the time during which new medications earn a return on investment, making each new product more expensive before it graduates to generic status.  This shorter product life also urges quicker churning of new, patent-protected products in to the market, which similarly increases costs to the consumer and, more importantly, the institutional payer (i.e., insurance, the most prominent of which is Medicare).</p>
<p>Thanks,</p>
<p>Robert</p>
<p>PS.  Joe, hope all is well with you, your bride, and the kids.  </p>
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		<title>By: Joe Ponzio</title>
		<link>http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development/#comment-1867</link>
		<dc:creator>Joe Ponzio</dc:creator>
		<pubDate>Mon, 23 Jun 2008 19:42:02 +0000</pubDate>
		<guid isPermaLink="false">http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development#comment-1867</guid>
		<description>It seems like we have a very interesting split here. On the one hand, people are chomping at the bit to buy Pfizer; on the other hand, it appears highly speculative to many.

I do think Pfizer is somewhat (but not way) underpriced right now relative to its value if the company&#039;s pipeline produces some promising results. If not, Pfizer may be underpriced today, but its value will drop as the sales (and cash flows) drop when Lipitor expires.

Here&#039;s the question, to which I do not have an answer yet: What will Pfizer do to keep its value up when that patent expires. Generating some $10 billion in owner earnings today, what will it do to preserve the value down the road. If it will generate less -- say, $6 billion in 2012 -- the value will plummet if the company does not buy back 40% or so of its shares from now til then.

It has the cash flow to do so assuming it cuts its dividend. Generating about $1.48 a share in owner earnings, if it keeps the dividend at $1.10, it won&#039;t be able to do much of a buyback without assuming some debt.

Pfizer&#039;s options?

&lt;ol&gt;&lt;li&gt;Get something promising out of the pipeline and into the market, and/or&lt;/li&gt;

&lt;li&gt;Cut the dividend and start buying back shares.&lt;/li&gt;&lt;/ol&gt;

Not sure which way this will play out? Check out one of the other 10,000  opportunities Mr. Market is dying to sell you!

&lt;b&gt;OpenMinded:&lt;/b&gt; Fisher should be read as a supplement to other books that discuss valuations. Without Fisher&#039;s (or similar) points, people would look solely to the past results to judge the future of a business, with potentially devastating consequences.

I wish Fisher would have talked more about valuation; still, I don&#039;t think people should skip the book simply because he doesn&#039;t.

My two cents.</description>
		<content:encoded><![CDATA[<p>It seems like we have a very interesting split here. On the one hand, people are chomping at the bit to buy Pfizer; on the other hand, it appears highly speculative to many.</p>
<p>I do think Pfizer is somewhat (but not way) underpriced right now relative to its value if the company&#8217;s pipeline produces some promising results. If not, Pfizer may be underpriced today, but its value will drop as the sales (and cash flows) drop when Lipitor expires.</p>
<p>Here&#8217;s the question, to which I do not have an answer yet: What will Pfizer do to keep its value up when that patent expires. Generating some $10 billion in owner earnings today, what will it do to preserve the value down the road. If it will generate less &#8212; say, $6 billion in 2012 &#8212; the value will plummet if the company does not buy back 40% or so of its shares from now til then.</p>
<p>It has the cash flow to do so assuming it cuts its dividend. Generating about $1.48 a share in owner earnings, if it keeps the dividend at $1.10, it won&#8217;t be able to do much of a buyback without assuming some debt.</p>
<p>Pfizer&#8217;s options?</p>
<ol>
<li>Get something promising out of the pipeline and into the market, and/or</li>
<li>Cut the dividend and start buying back shares.</li>
</ol>
<p>Not sure which way this will play out? Check out one of the other 10,000  opportunities Mr. Market is dying to sell you!</p>
<p><b>OpenMinded:</b> Fisher should be read as a supplement to other books that discuss valuations. Without Fisher&#8217;s (or similar) points, people would look solely to the past results to judge the future of a business, with potentially devastating consequences.</p>
<p>I wish Fisher would have talked more about valuation; still, I don&#8217;t think people should skip the book simply because he doesn&#8217;t.</p>
<p>My two cents.</p>
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		<title>By: OpenMinded</title>
		<link>http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development/#comment-1866</link>
		<dc:creator>OpenMinded</dc:creator>
		<pubDate>Mon, 23 Jun 2008 15:18:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development#comment-1866</guid>
		<description>Hello everyone, 

I have a hard time reading Fisher. My big reason is that he doesn&#039;t incorporate price enough in the investment decision making process. In none of his 15 points does he mention it. I&#039;m skeptical of any investment philosophy where the message is &quot;any price is ok&quot;. 

My opinion is if one was given this one book to be their investment bedrock, speculation and not investment would be the likely outcome.

I would enjoy feedback.

Thank You.

</description>
		<content:encoded><![CDATA[<p>Hello everyone, </p>
<p>I have a hard time reading Fisher. My big reason is that he doesn&#8217;t incorporate price enough in the investment decision making process. In none of his 15 points does he mention it. I&#8217;m skeptical of any investment philosophy where the message is &#8220;any price is ok&#8221;. </p>
<p>My opinion is if one was given this one book to be their investment bedrock, speculation and not investment would be the likely outcome.</p>
<p>I would enjoy feedback.</p>
<p>Thank You.</p>
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		<title>By: Aaron Murray</title>
		<link>http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development/#comment-1865</link>
		<dc:creator>Aaron Murray</dc:creator>
		<pubDate>Mon, 23 Jun 2008 02:18:24 +0000</pubDate>
		<guid isPermaLink="false">http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development#comment-1865</guid>
		<description>Joe, 

I work on the fringe of the industry (an American CRO) and we serve mostly biotech with a small % of work for Big Pharma.  As a new investor, I feel this is a very speculative industry and I am leery of putting my money into it.  Your points on Teva are spot on - it does seem to be one of the few players that are not speculative. 

Great work as always,

Aaron</description>
		<content:encoded><![CDATA[<p>Joe, </p>
<p>I work on the fringe of the industry (an American CRO) and we serve mostly biotech with a small % of work for Big Pharma.  As a new investor, I feel this is a very speculative industry and I am leery of putting my money into it.  Your points on Teva are spot on &#8211; it does seem to be one of the few players that are not speculative. </p>
<p>Great work as always,</p>
<p>Aaron</p>
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		<title>By: jay</title>
		<link>http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development/#comment-1863</link>
		<dc:creator>jay</dc:creator>
		<pubDate>Sun, 22 Jun 2008 19:22:14 +0000</pubDate>
		<guid isPermaLink="false">http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development#comment-1863</guid>
		<description>Wyeth (WYE) is another mid-parm.  The 2007 data point

&lt;table cellpadding=&quot;0&quot; cellspacing=&quot;0&quot; border=&quot;0&quot;&gt;

&lt;tr&gt;&lt;td class=&quot;ptlh&quot;&gt;&#160;&lt;/td&gt;&lt;td class=&quot;pth&quot;&gt;ROA&lt;/td&gt;&lt;td class=&quot;pth&quot;&gt;ROE&lt;/td&gt;&lt;td class=&quot;pth&quot;&gt;Free Cash/

Sale&lt;/td&gt;&lt;/tr&gt;

&lt;tr&gt;&lt;td class=&quot;ptdesc&quot;&gt;WYE&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;28.09%&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;28.09%&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;20.02%&lt;/td&gt;&lt;/tr&gt;

&lt;tr&gt;&lt;td class=&quot;ptdesc&quot;&gt;GSK&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;18.44%&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;54.92%&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;20.45%&lt;/td&gt;&lt;/tr&gt;

&lt;tr&gt;&lt;td class=&quot;ptdesc&quot;&gt;PFE&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;7.08% &lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;11.96%&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;23.70%&lt;/td&gt;&lt;/tr&gt;

&lt;tr&gt;&lt;td class=&quot;ptdesc&quot;&gt;LLY&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;12.12%&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;23.96%&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;21.85%&lt;/td&gt;&lt;/tr&gt;

&lt;tr&gt;&lt;td class=&quot;ptdesc&quot;&gt;TEVA&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;8.90%&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;15.70%&lt;/td&gt;&lt;td class=&quot;ptdata&quot;&gt;13.51%&lt;/td&gt;&lt;/tr&gt;

&lt;/table&gt;

So from ROA and ROE point of view, WYE is a well run company,  PFE is worst.  If you look back history, GSK is best run company, followed by WYE and LLY. Although FreeCash/Sale is mostly around 20% in 2007 for these companys as shown above, PFE is the only one shows the ability to consistently convert 20-25% into free cash ?  Also the dividend yield is highest for pfe, 7%</description>
		<content:encoded><![CDATA[<p>Wyeth (WYE) is another mid-parm.  The 2007 data point</p>
<table cellpadding="0" cellspacing="0" border="0">
<tr>
<td class="ptlh">&nbsp;</td>
<td class="pth">ROA</td>
<td class="pth">ROE</td>
<td class="pth">Free Cash/</p>
<p>Sale</td>
</tr>
<tr>
<td class="ptdesc">WYE</td>
<td class="ptdata">28.09%</td>
<td class="ptdata">28.09%</td>
<td class="ptdata">20.02%</td>
</tr>
<tr>
<td class="ptdesc">GSK</td>
<td class="ptdata">18.44%</td>
<td class="ptdata">54.92%</td>
<td class="ptdata">20.45%</td>
</tr>
<tr>
<td class="ptdesc">PFE</td>
<td class="ptdata">7.08% </td>
<td class="ptdata">11.96%</td>
<td class="ptdata">23.70%</td>
</tr>
<tr>
<td class="ptdesc">LLY</td>
<td class="ptdata">12.12%</td>
<td class="ptdata">23.96%</td>
<td class="ptdata">21.85%</td>
</tr>
<tr>
<td class="ptdesc">TEVA</td>
<td class="ptdata">8.90%</td>
<td class="ptdata">15.70%</td>
<td class="ptdata">13.51%</td>
</tr>
</table>
<p>So from ROA and ROE point of view, WYE is a well run company,  PFE is worst.  If you look back history, GSK is best run company, followed by WYE and LLY. Although FreeCash/Sale is mostly around 20% in 2007 for these companys as shown above, PFE is the only one shows the ability to consistently convert 20-25% into free cash ?  Also the dividend yield is highest for pfe, 7%</p>
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		<title>By: Rene</title>
		<link>http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development/#comment-1862</link>
		<dc:creator>Rene</dc:creator>
		<pubDate>Sun, 22 Jun 2008 17:55:03 +0000</pubDate>
		<guid isPermaLink="false">http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development#comment-1862</guid>
		<description>I&#039;m actually not a big fan of big pharma.  Yes, I know the baby boomers are going to be frantically buying that next miraculous hair loss prevention pill, whose only side effects will be kidney failure, sexual impotence, ninety-percent chance of a heart attack and severe halitosis, but somehow, I don&#039;t think that business model is sustainable.  Pfizer seems different to me.  Not only do they have two huge blockbusters in Lipitor and Viagra, but both of these drug&#039;s side effects are beneficial and are even prescribed for conditions other than their main intended one.  For me, this makes Pfizer the best of all possible investments, not a Hank Aaron and not a Pete Rose, a Ted Williams.  This company will do as well as it&#039;s competitors, but will also hit it out of the park often.  Maybe I&#039;m seeing integrity and thoroughness where I should just see luck, but that is my impression.

Having said all those nice things though, the numbers are still not quite right and there are several worrisome issues that keep me from pulling the trigger just yet.  The Democrats will be reversing some of that industries sweetheart deals like the &quot;no price negotiation&quot; clause with medicare and the absurd restrictions on importation from places like Canada and the E.U. and the company will take a hit if it either cuts the dividend or repatriates dollars to pay said dividend, it has to do one or the other...unless it hits some kind of R&amp;D jackpot soon.

</description>
		<content:encoded><![CDATA[<p>I&#8217;m actually not a big fan of big pharma.  Yes, I know the baby boomers are going to be frantically buying that next miraculous hair loss prevention pill, whose only side effects will be kidney failure, sexual impotence, ninety-percent chance of a heart attack and severe halitosis, but somehow, I don&#8217;t think that business model is sustainable.  Pfizer seems different to me.  Not only do they have two huge blockbusters in Lipitor and Viagra, but both of these drug&#8217;s side effects are beneficial and are even prescribed for conditions other than their main intended one.  For me, this makes Pfizer the best of all possible investments, not a Hank Aaron and not a Pete Rose, a Ted Williams.  This company will do as well as it&#8217;s competitors, but will also hit it out of the park often.  Maybe I&#8217;m seeing integrity and thoroughness where I should just see luck, but that is my impression.</p>
<p>Having said all those nice things though, the numbers are still not quite right and there are several worrisome issues that keep me from pulling the trigger just yet.  The Democrats will be reversing some of that industries sweetheart deals like the &#8220;no price negotiation&#8221; clause with medicare and the absurd restrictions on importation from places like Canada and the E.U. and the company will take a hit if it either cuts the dividend or repatriates dollars to pay said dividend, it has to do one or the other&#8230;unless it hits some kind of R&#038;D jackpot soon.</p>
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		<title>By: Paul</title>
		<link>http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development/#comment-1861</link>
		<dc:creator>Paul</dc:creator>
		<pubDate>Sun, 22 Jun 2008 15:14:49 +0000</pubDate>
		<guid isPermaLink="false">http://www.fwallstreet.com/article/139-whats-happening-with-research-and-development#comment-1861</guid>
		<description>Another nice post.  Good point on Teva.  I wasn&#039;t aware they didn&#039;t produce patented drugs, takes some of the guess work out of valuing their future prospects with no phase trials to contend with.

Paul </description>
		<content:encoded><![CDATA[<p>Another nice post.  Good point on Teva.  I wasn&#8217;t aware they didn&#8217;t produce patented drugs, takes some of the guess work out of valuing their future prospects with no phase trials to contend with.</p>
<p>Paul </p>
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